You play alternately Alien and Predator.
Opponents are different. Marines, Cyborgs, Predators and Aliens all possible from hatchling to the Queen, APC tank, dropships and even a shipper like in the movie.
There are many unlockable weapons and upgrades. The points for it can be very well earn (Here are the unlockable challenges especially), so you have to spend money on better equipment.
The difficulty degree is right, even with the best equipment you die yet (only the raid bosses I felt a bit weak).
Conclusion: strong buy recommendation for genre fans (except for people with a weak stomach).
My Galaxy S3 came at medium graphics setting. a good sweat.