+ Cooling is more than adequate, even at high temperatures in the Indian desert; However, it can be expected no refrigeration on level of a refrigerator; the Frio-bag adheres rather cool permanently discreetly; Important here: Insulin is much more robust than will make it one of the pharmacists around the corner always white, as long as values are adhered to around 20 ° C, there is no problem.
+ Activation of the bag requires only water; a big advantage when traveling in developing countries.
+ Without activation (ie no recorded water) cooling bag is very easy. I have enabled the bag only after arrival in the destination country and deactivated by plane again before departure; presumably there could be problems in the security sector with the activated Frio bag in hand luggage.
+/- The evaporative cooling operates only on dry ambient air; that is, the cooler should be whenever possible, removed from the backpack in order to really work well can.
+/- To the longevity of my pocket, I can not say anything; during the month in India I have the bag 4 - 5 times charged; without any problems.
In my opinion, there is no reasonable alternative to the Frio-bag when traveling in less developed regions, thereby wants to be independent of electricity or ice packs. Five Stars!