I normally take Mastodynon for PMS and breast pain, Which contains agnus castus as The Main Ingredient. As did product works extremely well, I was thinking of switching to the pure, organic agnus castus tincture. A while after starting to use this product, I became very sick and my breasts started being extremely tender. As soon as I stopped using it, things went back to normal. I am now taking Mastodynon again ..