Effective from the first use: improved breathing, sleep more restful. I no longer have the difficult awakenings (fatigue, pain), blood is better oxygenated, more daytime sleepiness, and curiously I no longer that imperious need to go urinate early night! Cause and effect on the bladder ??? That's because I sleep better without doute.Et I feel more in the mood to face the people who pump us up! I started with the S, that suits me. At the first use I was itching on grattouillaient nostrils, already sensitized by acid runoff from chronic rhino (with feeling stuffy nose). I apply almond oil with 1 gte of HE Lavender (in the palm of the hand) on a cotton swab to brush the inside of the nostrils. Soothing effect on mucous membranes, but also for sleep (and better than any cream (be careful with sensitive mucous membranes and to what snife.) Later I put the ring. One quickly gets used to this ring and if the right size is used, it does not lose it (if you do not put too much oil! Blow your nose before placing the ring!) It is not necessary to go all the way in. If this hurts is that it is not well placed, too deep or too large. After a few tries you easily calerez in the nostrils and it has tiny hooks on the outer sides. If it feels it is less effective after a few days, we can move up a size, pushing least, nostrils were made at the spacer and the nose is less sensitive to the presence of this object. Continue nasal washes several times a day and also wash the spacer. aerated pits but the time to do household in time! Is the price a little expensive because it must be renewed every 3 months. But what works is expensive ...