I see some negative comments and different! It is necessary that a product may be effective on some and not on others. For me I have a positive effect. The buttons are so big and fewer. In my case, no puberty story! I'm 40 and skin problems are present for my 11 years. I had many treatments and creams, but never managed to get rid of this troublesome problem. Especially 40 years. Today I Clearzine with virtually no worries. From time to time a little coming out here and the .. but nothing compared to before. So for me it is positive ...