We had this mouse actually ordered in the first place because of their ergonomic features. I myself was the first test subject and am very confident of the unit personally. The size of my hand is to be considered rather than average, nothing special so. This mouse (CSL - TM137U Optical Mouse / vertical version | ergonomic design -) is excellent in hand. If you put your hand on the mouse, the mouse's natural cavity fills almost by itself, to the relaxed hand forms naturally. Result: You can feel the work on the mouse and can therefore hardly a long time to work hand-fatigue with this device. All the buttons and the scroll wheel are easily accessible for me and also smoothly. * Although Yes, and and distinguishable in the picture blue LED arc which makes it clear that the mouse is connected may not be mandatory, but "he did something." * We have therefore equal to a few Exemlare the unit for our PC users (inside) ordered. In my view therefore an unrestricted Purchase Recommendation!