From the description (not even from the description on the website Yubico) It is not clear that at this key moment (and deliberately) only OTP * or * U2F can be enabled as FIDO clients (eg web browser) can run into problems when both protocols are simultaneously active on the Key. Thus, the YubiKey NEO may immediately until the (lying outside the responsibility of Yubico) are solved problems, for example. (At times to name two popular services) only for Google accounts (requires U2F) * or * for LastPass (requires OTP) used are, do not want to reconfigure every awkward to him. There are already a workaround, in which, however, can suddenly "bricken" his Key. Who wants to try it anyway, read here: [...] or here: [...] ADDENDUM: With the release of the YubiKey NEO Manager in Version 1.0 can now finally all three protocols (CCID, OTP, U2F) * * simultaneously activated without risk. Prerequisite is the firmware 3.3 on the stick and Google Chrome version. 39 Then I raised my rating to 5 stars!