I use this bag a year since + 3.5 with several drives Iomega Desktop 500GB LaCie Rugged XL and 1 T. One can store your power supply and cables without problems. Only particular care to bring: fully open the zipper as it is by building on the axis of rotation of the cover and the simple forgetting of course do so could cause damage. Moreover padding provides a "standard" protection but is probably not designed for severe impact. However, I fear this glides in my panniers (embedded in a sweater). In these conditions the product there is quite satisfactory.