Whatever Logitech may have been thinking, but if you want to save the button assignment in the mouse (very useful thing by the way, one does not rely on any software), then the keys are left and right of the scroll wheel with "left click" and " Right-click "fixed assignment, and you can not change, as long as one does not access screwdriver and soldering iron.
Otherwise, the mouse is really nice: it is really good in the hand, has a pleasant weight, the main keys to operate well and she has the rare and favorite of mine layout with three buttons for the index, middle and ring fingers with the scroll wheel arranged between the two left. Only the cable could be softer.
The tens of modifier keys I use currently is not, so I can say this, nothing.
All in all a comfortable replacement for the old triangular mouseman I've used all the time - but unfortunately only after the rewiring of the two right buttons ...