The backpack is really top. Very well made, nice and big, so my whole Accessories (Nikon D700 + Nikkor AF-S 28-70 2.8 ED top, other lenses, the SB-900 flash adapter, replacement batteries, Ladegaräte etc.) fits with pure. Comfort is also very good, at least on my back. So from me a strong buy recommendation. I have tried several backpacks in stores. All were either too small or too ugly. The Lowepro Pro Runner 300 AW, I have found my absolute favorites. However, if a smaller backpack for "easy" tours where only the camera with an objective should be part investigated, to look at something else. Because in the above designed backpack already fit in some and therefore it is not small.
Update 11.10.2012:
now I have given up my Nikon equipment and am now traveling with Canon. I currently have a Canon 5D Mark 3, Canon BG E-11, Canon 24-70L USM I, a Canon 17-40mm L USM and a 50mm f / 1.8 prime lens. 5D Mark 3 fits with screwed-BG and the Canon 24-70L USM I purely easily when they are placed laterally. My other lenses (17-40L, 50mm FB) + Canon Charger Canon 430EX II + + + diffuser charger Biltzakkus (Eneloops) + bellows and fit even pure. There is even some space available, for example, even a medium-sized lens. I would recommend the backpack still. It is worth the money and has never let me down.