The sound difference is clearly audible, on a mahogany Strat previously brilliant heights are gone, everything moves very in the middle, the bass foundation remains virtually unchanged. This works pretty well clean with pleasant warm sound, crunch and high gain but lacks the bite. Ups and Zerre may be readjusted.
Conclusion: plenty of feel, the sound may change but quite (and of course guitar dependent) constitute more than the much mentioned herein Nuance. Just try to help.