One might think that scientific research must, in essence, from the questioning of the acquis. From 12 examples of researchers from the last century, the LANCE book shows that it is then, however, a dangerous path that exposes you to rejection and elimination by those who are already well established in the system and who have an interest, financial or otherwise, that it continues as it is. There are disagreements, they give rise to more or less heated debates that the authorities show up some resistance the contetation ideas or established situations, certainly: but blockages, persecution, denial of justice which may have been exposed these original pioneers from what LANCE called nomenclature defies the imagination and reason. Through these 12 examples, and beyond the self-interest of each, it delivers us raises awareness of the enormous resistance that opposes, in our societies, the truly radical innovations. Great, to read and to read. jc Faffa