Try this game - you're in the main menu, your cursor flickers etc.
ALT + TAB - then desktop ALT + TAB - the game
Now starts a game - no flickering, no imaging problems etc.
Once in the game - again flicker etc.
Repeats just the tabbing.
And Zack runs all the fun without any errors. Sometimes seems to respond only slightly ill.
(Tested on a laptop with AMD A10 + AMD HD8610 display with dedicated R7 M270)
(So do not mind if it does not work out with you, with me is supi :))