We actually bought the product, because it should be a natural painkiller. Our 9-year-old bitch now has joint problems, but in spite of MSM and lipped we have seen no improvement. But what we can not say: It is possible that the state would have deteriorated without these additions yes. After all, their state for about 3 years stable and ..... what more could you want. Addendum, 10:09:14: Now we the powder had run out, and we thought we try it without. The result was disastrous. Our dog was limping and had seeeehr intently while running. Toben was not. - So buy again powder ... It took a good week, but she's doing much better. I can hardly believe it !!!!