The mouse buttons have a clear pressure point of the mouse wheel (middle mouse button) is indeed quite strong and so far getting used to - but getting used capable. Inadvertent tilting the wheel left or right, I could not tell: If you want to use the mouse wheel as a click function, generally has in all mice rather the problem of unwanted scrolling up or down - mouse dyslexic be the function of the middle mouse button under the scroll wheel safely anyway want to avoid.
The interaction with Windows standard drivers or to increase comfort with the Logitech SetPoint suite is expected to well. At the Mac, for example, stay with ControllerMate nothing to be desired - possibly apart from the battery level indicator. - The Logitech Control Center for Mac displays it certainly, I have not tested (I do not use the LCC).
For very kind-hearted, over-sensitive mouse tamers like me: Yes, the mouse has a perceptible wake-up latency. After about 10-second inactivity the mouse falls into a doze, from which they must first be awakened. This is, however, very quickly: If the first mouse movement to wake up more filigree, noticed one hardly. If the first mouse movement but rather hectic, you take a little time delay true.
A serious gaming test run is still pending, but I do not really expect this with latency issues. Because: For strongly mouse-heavy work or game play, the latency is irrelevant, because the mouse long enough remains awake. But must go after prolonged keyboard operation phases with the first new handle to move everything quickly, sensitive contemporaries could this disturbing. - That this is also different, for example, shows Apple with their (otherwise for my taste rather unergonomic) cordless input devices.
I give the Logitech M505 now 4-6 weeks probation. From vigorous Mausradklick I expect no problems. Whether I can live as a wired mouse usual "Prince and the Pea" with the actually highest acceptable wakeup latency, however remains to be seen.
UPDATE: After more than 3 months, I have coped well with the M505 and the wake-up latency. I use the mouse five working days a week, at least 8-10 hours per day, I have never been turned off at the switch. On the missing for me at Mac Battery level indicator I can do without: a battery level of just under 90% will test ways hung on a PC with SetPoint software displayed - mind you: After a quarter of intensive professional use. This highly reckoning I predict the first battery change therefore for spring-2013.
A quick note yet: If the mouse react sometime erratic, it could be that a Staubflocke has put under the lens. Effective then helps a brief brush wiping - or even blow in short (because anno dunnemals in the module slot of the Gameboy).
