MSM in osteoarthritis: effects, side effects, dosage, application notes MSM has a pain-relieving and detoxifying effects. The sulfur contained in MSM is part of the cartilage structure so that cartilage-building effects are likely. Demonstrated the effects are so far not. MSM is a very safe means and has no side effects. The recommended dose to 1,500 mg daily. The combination of MSM with other natural remedies such as glucosamine has proven in studies to be beneficial. Other applications of MSM general sulfur deficiency, to lower the homocysteine level [5] to improve the blood circulation, to improve wound healing. These applications, however, are much less explored than the use in osteoarthritis and arthritis. MSM is also used in: general sulfur deficiency, to lower the homocysteine level [5] to improve the blood circulation, to improve wound healing. These applications, however, are much less explored than the use in osteoarthritis and arthritis. Safety of MSM: side effects, contraindications MSM is classified as a dietary supplement in the EU. It is very safe. Notable side effects were observed. Overdoses even with maximum effort, and intentionally hardly bring about. Overdose The dose could be poisoned in the test animals by MSM, is about 20 grams per kilogram of body weight. A person (75 kg) would have to take about 1.5 kg MSM per day. In tests on volunteers of this 1 gram per kg body weight (or about 60 90 grams daily) was ingested daily for a month. There were observed no negative side effects. [6] Recommended dosage The recommended dose is based on the studies daily between 0.5 grams and 4 grams. Dosages above should apply from general precaution, only under medical supervision. Also during pregnancy should not take MSM. But this is a general recommendation, because the data are not sufficient. The dosage information refers to oral administration (capsules, tablets). MSM is injected sporadically under the skin or as DMSO buried ointments. Please ask in particular to your therapist.