Whether one is clear is a great mouse, but especially useful for gamers. Although one can configure handy macros on Windows (Back, Forward, Close Window, Show Desktop, ...), the whole point of this mouse is in gaming, where she excels!
Buttons under the thumb:
6 of the 9 buttons are easily accessible without the risk of being wrong.
Hardware mode (use preferably), two of the remaining buttons can be used to switch profiles. In the shot, only one button is difficult to access for a small hand.
Warning - I read widely and designs, these buttons can be unusable for those who have very large hands !!
Comfort:
Nothing to say about comfort. The mouse fits perfectly the palm of the hand, and the cliques are really nice.
If the mouse is far from slight, very good gliding leaves quickly forget that little detail.
Disadvantage:
The only weak point I see is perfectible driver of the mouse.
Sometimes, when déplug replug, the mouse does not move when the lights are lit; it is then necessary to modify the "Lift Height" that it meets again; and without a mouse, it can be a little tricky ...
Another detail; if you decide to use Sofware mode driver (which automatically switch profile depending on the application), the small LED next to the thumb are no longer usable and will show you more about what profile you are (all just because in software, the number of profile exceeds the number of LEDs). This can be a bit annoying if you use multiple profiles for the same application (Game).