Given in a large dog with two doses per day, this product has given undeniable results. The vet has confirmed the quality and efficacy. (He has no interest in the case, because it is a vet who comes home and does not sell "related products"). We use two to three times per year in maintenance and cure our akita inu has gorgeous teeth. All for a price two to three times lower than those in the shops of local commerce! We can only recommend.