Although there is no Mac drivers from Epson for this printer, it can be with the general "Epson 9-pin" driver (part of standard Insatllation of Mac OS X) operate smoothly. The printer hangs with me via USB to an AirPort Express, is thus fully involved in my WLAN and print reliably every day a couple of 4-layer shipping documents. All in all, he is so exactly what I was looking for. 5 star there would be if Epson would mitliefern a Mac driver and the design would be a little bit nicer.
Update June 8, 2015: Even after more than 5 years print the LX-300 + II regularly, without a murmur and without failures, to a Mac with Yosemite. Great Thing!