as required - we will use the real Manuka honey with 100 or 250 or 400th My mother is 85 years old and went regularly to the flu shot. As the last year has not been possible (constant colds, infections - and numerous hospital stays), she has instead taken in autumn to the 250er and 400er Manuka during the winter months. And it came wonderfully through the cold season. Even now she takes the Manuka when a cold or discomfort sneaking. And when our dog has suffered a major wound in the virgin, the extended period of time did not heal, we gave him the manuka honey to the wound. This was healed on the 3rd day, although previously still open. Is really amazing, but for those of us who have witnessed the live, now totally convincing. I pay attention now that I have these three different strengths always at home.