Unfortunately, I have now been demolished several of them. Even for the 4x40 screws you have to pre-drill or lubricate with wood, because these often tear otherwise.
Especially annoying when I turned a screw in a Tox anchor is even the bolt ripped - that must not happen!
Another problem is when you vorbohrt even only 2mm for a 4mm screw catch the screws quickly pluck at the threads and to spin, that should not be in too.
In the end you always have to tear out and in with full drill with tear make a balance between pre-drill.
I hope now that hold the screws already installed, otherwise I may make me do all the work well again soon.