Contrary to what is indicated by Logitech, this remote works very well MacOSX (10.6) for controlling PowerPoint or Keynote. The only condition: UNINSTALL THE LOGITECH CONTROL CENTER, which is a shame. As I also have a multi-button mouse from Logitech, I just installed a very good shareware (Steermouse) instead. And everything works fine now. The remote is very nice, very visible green laser even in a bright room, and easy to set timer. The only flaw is that the buttons front / rear and laser is the same feel and therefore takes a little practice to find its footing. A great product for Mac anyway.