We had at the beginning of the MSM 1000 and MSM are changed to 1500 after the body has adapted. If one (1000 he) takes the MSM for the first time (1 x breakfast, 1 x dinner) you will after a few days a slight pressure in the head feel and get possibly a slight headache. The places but after 3-4 days. Since then, we take these pills regularly, we have no More headaches. I had suffered from tension headaches, especially when the weather changes by the change in air pressure. This is now all gone. In addition, our family doctor says that the MSM over time improve everything, as many minerals that the body needs are contained. We are concerned in any case very well. The Constitution has become much better, somehow it is much more powerful and simply feels just fine.