I was discouraged by Frontline multiple instances - even from the vet - because it allegedly does not work properly. I have a 37 kg Dogue de Bordeaux and have (yes I admit it) Frontline ordered because it is low. I wanted to try it anyway because one can not go far wrong with the price. The application is very simple, I have instilled just one half of the vial on the skin on the neck and the other half on the skin of the tail. I always do the evening so I did not immediately blurs if my dog demands their pats. I have now run out of the 5 6 ampoules (which I have given her during the winter months not) and they had a total of a single tick! I am totally surprised because I have heard only negative but I can only confirm the opposite. I am often the wäldlich live with my parents and this year there are a lot of ticks - yet she has the last visits survived completely free from ticks. Even in everyday life, it is a day in the fields and in forests on the way. I can not recommend highly enough the means - the vet I have paid three times for a tick, what I now consider to be completely unnecessary.