In contrast to the large hand button are a bit small and the buttons (10,11,12) in back of the mouse are not easily achievable.
Also know the buttons on the side of 1 to 12 represents the numeric keypad (impossible to independently binder affects the keypad).
If the mouse sensor tends to often pick on certain surface (shiny black and matte)
For the rest it is a very good mouse, pretty customizable color, good battery life wireless and wired facielemnt convertible (5 Seconds).